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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinopathy of prematurity (ROP)
ncRNA name LPA1 shRNA
ncRNA Category shRNA
Disease name retinopathy of prematurity (ROP)
Species Mus musculus
Tissues/Cell_line retinal ganglion cell line RGC-5
Methods shRNA knockdown, Western blot, qPCR
Expression pattern associated
Functional description Exposure to stearoyl-LPA or hypoxia substantially reduced the viability of RGCs. This was abrogated by THG1603 and shRNA-LPA1.
PubMed ID 18978343
Year 2009
Title The role of lysophosphatidic acid receptor (LPA1) in the oxygen-induced retinal ganglion cell degeneration.
Drug-related ncRNA NA

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